August 13, 2019

An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

Frontiers in Chemistry 2019; Volume 7, Article number 568

Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.

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Other Autors

Carmine Ostacolo
Veronica Di Sarno
Tania Ciaglia
Vincenzo Vestuto
Giacomo Pepe
Fabrizio Merciai
Pietro Campiglia
Isabel M. Gomez Monterrey
Alessia Bertamino