Focus Oncotherapies #4

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June 26, 2020

Focus Oncotherapies #4

The relationship between the bacteria present in the intestine and the risk of developing pathologies, even serious ones, including cancer, becomes increasingly evident.

In the study "Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce Its Bioavailability and Chemopreventive Effects" carried out by the "Chinese University of Hong Kong" the authors used a mouse model of colorectal cancer to evaluate whether aspirin administration could lead to to the reduction in the number of tumors.

The results of the study showed that aspirin was able to prevent the appearance of colon cancer. At the same time, the researchers showed that the presence of a particular bacterial species (Lysinibacillus sphaericus) strongly reduced the beneficial effects induced by the administration of aspirin, as these bacteria are able to degrade it.

This study teaches us how the clinical response to a drug depends on several factors, including the gut microbiota.


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