usually the result of a combination of factors that contribute to increase (or
protect from) the risk of cancer development. Six factors were already
described as important for cancer progression: immortality, the ability to
evade apoptosis, to sustain angiogenesis, to produce self-sufficient growth
signals, to ignore anti-growth signals, to replicate limitless and to invade
In 2009, an Italian study officially named inflammation as the seventh factor. The inflammatory microenvironment favors tumor growth, this was known for chronic inflammatory syndromes. Patients affected by chronic intestinal inflammation are more susceptible to develop colorectal cancer. Inflammation is a defense mechanism but requires tight control mechanisms.
EBRIS is involved in studies devoted to highlight the axis between inflammation and cancer and to develop strategies to control inflammation and reduce cancer risks.