March 1, 2021

Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin

DovePress Volume 2021:16 Pages 1617—1630

This work was supported by the Italian Ministry of Health- Ricerca Corrente project, by the PRIN-2017A2KEPL project and by the grant from Regione Campania-POR Campania FESR 2014/2020 “Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie-Campania Oncoterapie”

The clinical use of the antitumoral drug doxorubicin (Dox) is reduced by its dose-limiting toxicity, related to cardiotoxic side effects and myelosuppression. In order to overcome these drawbacks, here we describe the synthesis, the structural characterization and the in vitro cytotoxicity assays of hydrogels (HGs) and nanogels (NGs) based on short peptide sequences loaded with Dox or with its liposomal formulation, Doxil.


Other Autors

Gallo E.
Diaferia C.
Rosa E.
Smaldone G.
Morelli G.
Accardo A.